General information

Hepatobiliary&Pancreatic Diseases International is a journal published bimonthly in the English language by the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China.We welcome original research articles,review articles,editorials,and others from any part of the world.Manuscripts are reviewed by members of the international editorial board and our expert peer reviewers,then either accepted for publication or rejected by the chief editor.Manuscripts should be submitted via https://mc03.manuscriptcentral.com/hbpdint.

Most of submissions accepted for publication may undergo revisions recommended by the reviewers,editors or statistical advisers.A decision takes from two weeks to three months,the longer period being due to the multiple reviews needed for articles likely to be accepted.Publication varies from two to six months after final acceptance.Proofs of edited articles and illustrations are sent to the corresponding author for correction and reply to any queries from editors.A sample copy of the journal containing the articles will be forwarded to the corresponding author within a few days of publication.

Online submissions

Original research articles including randomized trials,intervention studies,studies of screening and diagnostic tests,cohort studies,cost-effectiveness analyses and case control studies should be prepared in accordance with the Uniform Requirements for Manuscripts Submitted to Biomedical Journals(www.icmje.org).Those of randomized controlled trials(RCTs)should follow the CONSORT-statement(www.consort-statement.org).The reporting of other articles should follow the guidelines set by the different initiatives or groups listed in the appendix.The article should be submitted with two separate files,one with detailed information about authors and the title,short running title,source of the work,in addition to the names,address,telephone and fax number or E-mail address for the corresponding author.Another file should show only the title,running title,abstract,main text,tables, figures of the submitted article as well as a list of references,which will be sent to reviewers.

The authors’names(normally no more than six)and their initials should be in the same form as in their other publications with one major quali fication such as MD or PhD,their current appointment and a full postal address.One author should be named for editorial correspondence.

Each submission must be accompanied by a letter of copyright transfer signed by all the authors(see the detailed description in the last section)and other relevant documents including informed consent obtained from research subjects and research approval from the supervising or institutional ethics bodies.Author(s)of each submission should clarify the functions in or contributions to their research and declare,if any,competing interest.A choice of one of the following statements will be requested when a decision has been made to accept the paper:

1.The author or one or more of the authors have received or will receive bene fits for personal or professional use from a commercial party related directly or indirectly to the subject of this article.

2.No bene fits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.

3.The author or authors do not choose to declare any conflict of interest related directly or indirectly to the subject of this article.

The statements selected by the author or authors will be published with the article.The signature of each author will be required.No article will be published until the completed form has been received at the Hepatobiliary&Pancreatic Diseases International office.

Manuscripts should be prepared with generous margins,and double spacing is essential throughout the text,the references and the captions.Tables, figures,captions and list of references should appear properly in the text.The style should be simple and direct,free from ambiguity and jargon,and with minimal use of abbreviations.

The title of the paper should be chosen with care:a short one has more impact and may be expanded by a subtitle.

Structured abstract of original articles should include four sections as Background,Methods,Results and Conclusions and have no more than 300 words summarizing the most important points in the article,incorporating key words suitable for electronic retrieval systems.Background:This section should provide a precise statement of the primary focus of the study and the context in which it was carried out.Methods:This section describes how the study was performed,including details of clinical and/or technical procedures.Results:This section describes the salient results of the study.Conclusions:This section covers conclusions and their clinical application or others,while equal emphasis should be given to positive and negative findings of equal scienti fic merit.

The main text should be divided under headings.For many research papers the best sequence is Introduction,Methods(Materials or Patients),Results,and Discussion.The text should comment on,but should not repeat,the details given in tables, figures or captions.Any acknowledgements should be made at the end of the main text.

Online journals with volume and page information

Methods(Materials or Patients):The subjects of the study and the methods employed in the investigation must be clearly described.For example,the reasons for examining the particular group of patients should be made clear,and reasons for exclusion of individuals from the study must be stated.Any group used as controls must be de fined accurately.

Ethical approval of studies and informed consent are required.For all manuscripts reporting data from studies involving human participants or animals,formal review and approval,or formal review and waiver,by an appropriate institutional review board or ethics committee is required and should be described in the Methods section.For those investigators who do not have formal ethics review committees,the principles outlined in the Declaration of Helsinki should be followed.For investigations of humans,state in the Methods section the manner in which informed consent was obtained from the study participants(i.e.,oral or written).Editors may request that authors provide documentation of the formal review and recommendation from the institutional review board or ethics committee responsible for oversight of the study.

Results:These mustbe clearly expressed in simple language.Tables or similar diagrams can be used but must not duplicate material already described in the text.

Discussion:This section must be succinct,pointing out the relevance of the work described in the article and its contribution to current knowledge.The results must be interpreted clearly,and both strength and weakness expressed.Discussion of pertinent references must be concise and short.

五年后，我大学毕业时，老马还在写诗，已经是个小有名气的农民诗人。虽然依旧在种地，但他有了一点难得的感悟：诗歌可能与稻草有关系，但一定和职业没有关系。别人可以把爱诗和写诗的人当成怪物，但诗人自己不能。

姑父倚在沙发上，整个身子填满在沙发里，边看电视，边和小虫说话，半天一句，问小虫最近工作怎样，和领导关系怎样，小虫都说好。姑父又给了小虫一些教诲，工作认真些，手脚勤快些，脑子活套些，别整天吊儿郎当的。小虫一直嗯着，脸上堆着谦卑的笑，不敢多言，怕说错了话。在姑父面前，小虫一直很拘束，很谨慎，不像在姑妈面前有说有笑，口无遮拦。

Each of the tables should have a short descriptive heading.

The references in the text should include only those that are importantand have been studied fully by the authors.The authors are responsible for the accuracy and completeness of the cited references and for correct citation of the text.When listing references the names of journals should be abbreviated according to Index Medicus(List all authors and/or editors up to 6;if more than 6,list the first 6 and et al).All references will be checked deliberately by the authors;PMIDroots in the abstractserialnumber indexed by PubMed(http://www.ncbi.nlm.nih.gov/sites/entrez?db=PubMed)and doi are requested.The references cited should be represented in the text by numbers within square brackets in the order of their appearance.The list of references at the end of the text should be in this numerical order with details and punctuation as follows:

Article from journal—more than one author

Cen C,Fang HX,Yu SF,Liu JM,Liu YX,Zhou L,et al.Association between ADIPOQ gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation.Hepatobiliary Pancreat Dis Int 2017;16:602-609.PMID:29291779 doi:10.1016/S1499-3872(17)60069-9.

RCT with non-inferiority/equivalence design

Notes,news or announcements for conferences,symposia or meetings may be sent for publication at least 3 months before the required date of publication.These are mostly included under Meetings and Courses without payment.Provide title,date(s)and place ofthe eventand contactaddress,telephone,and E-mailaddress.Hepatobiliary&Pancreatic Diseases International reserves the right to be selective in publishing these announcements.Those wishing for a detailed publication may submit as advertisements.For academic information,subsidized rates are available.

Sun JH,Zhang YL,Nie CH,Li J,Zhou TY,Zhou GH,et al.Effect of liver cirrhosis on percutaneous selective portal vein embolization for primary liver cancer[Article in Chinese].Zhonghua Yi Xue Za Zhi 2013;93:3831-3834.PMID:24548443 doi:10.3760/cma.j.issn.0376-2491.2013.48.006.

1.3 差异表达基因筛选 利用R软件limma包[10]筛选差异表达基因，得到肾透明细胞癌与正常肾组织间差异表达基因用于共表达网络的构建，筛选条件为：FDR<0.05，| log2 FC|≥1.0，其中FC为fold change即两组间差异表达倍数。

Monographic series

Davidoff RA.Migraine:manifestations,pathogenesis,and management.Philadelphia,Pa:FA Davis;1995.Contemporary Neurology Series,No.42.

Introduction:This should explain the problem which is to be addressed,with a de finition of the hypothesis to be examined if appropriate,out-lining,brie fly,its relevance to the appropriate literature.

1.3 仪器设备 Logic E9／E8 XD-Clear彩色多普勒超声诊断仪2台，采用频率10～13 MHz线阵探头。选用18G的日本八光PTC穿刺针；10 mL、20 mL一次性注射器。

Simon JA,Hudes ES.Relationship of ascorbic acid to blood lead levels.JAMA 1999;281:2289-2293.PMID:10386552.Accessed June 11,2009.http://jama.ama-assn.org/cgi/content/full/281/24/2289

Online journals without volume and page information

Li JH,Jia JJ,Shen W,Chen SS,Jiang L,Xie HY,et al.Optimized postconditioning algorithm protects liver graft after liver transplantation in rats.Hepatobiliary Pancreat Dis Int 2018 Feb 2.PMID:29428101 doi:10.1016/j.hbpd.2018.01.006.

3.处理好与其它成员的关系。在日常审计工作中，为审计组成员树立表率。同时要尊重、关心审计组成员，摆正位置，合理分工，使其各司其职，各负其责，充分发挥审计成员的主观能动性和责任意识，积极营造分工明确，团结协作的默契氛围。

Online website

随着研究门类的增长和多样化，爱丁堡大学也在逐渐扩大校区，现在已有6个主要校区。中心校区（Central Area）是爱丁堡大学最古老的校区，著名的旧学院（Old College）就坐落在这里。中心校区兴建于1789年，由著名建筑家罗伯特·亚当设计，而此前爱丁堡大学并没有专属的校园。旧学院位于爱丁堡老城的南桥街，现在是法学院等学院的所在地，附近有著名的苏格兰国家博物馆。

Morse SS.Factors in the emergence of infectious diseases.Emerg Infect Dis[serial online]1995 Jan-Mar[cited 1996 Jun 5];1(1):[24 screens].Available from:www.cdc.gov/ncidod/eid/vol1no1/morse.htm

http://jama.ama-assn.org/cgi/content/full/295/10/1152

Baselt RC,Cravey RH.Disposition of toxic drugs and chemicals in man,4th ed.Foster City,CA:Chemical Toxicology Institute;1995.

Chapter from a book

Calne RY.Experimental background.In:Calne RY,ed.Liver transplantation,2nd ed.London:Grune&stratton;1987:3-7.

Book—with editors

Maddrey WC,ed.Transplantation of the liver.New York:Elsevier Science Publishing;1998.

Illustrations Photographs,drawings,diagrams,charts and graphs should meet the editorial demands.The “three-dimensional”bar charts produced by computer programs are not acceptable.Photomicrographs with no inset scale should have the magni fication of the print in the caption;stains should be indicated.The lettering on diagrams and graphs should be large enough to be clear after it has been reduced for printing and be consistent in size and style.Color will be accepted only where it is essential.Permission to reproduce any borrowed illustration must be obtained from the author and the publisher,and evidence of this permission must accompany the submitted article.

Review articles are welcome especially systematic,critical assessments of the literature and data sources pertaining to clinical topics,emphasizing factors such as cause,diagnosis,prognosis,therapy,or prevention.All articles and data sources reviewed should include information about the speci fic type of study or analysis,population,intervention,exposure,and tests or outcomes.All articles or data sources should be selected systematically for inclusion in the review and critically evaluated,and the selection process should be described in the article.Meta-analyses also will be considered as review articles.Editors ask potential authors of review articles to check the MOOSE initiative for meta-analysis of observational studies in epidemiology(See the appendix).

Letters to the editor on matters of recently published articles in the journal are especially welcome,which should not exceed 400 words.Letters of general interest,unlinked to items published in the journal,can be up to 1500 words long and are to be sent for peer-reviewed.Correspondence letters are not usually peer reviewed,but the journal might invite replies from the authors of the original publication,or pass on letters to these authors.Only two tables or figures are permitted,and there should be no more than 10 references and six authors.All accepted letters are edited,and proofs will be sent out to authors before publication.

Appendix.Reporting guidelines for study designs

Study designs

Randomized controlled trial(RCT)–superiority design

设锚杆与锚固剂共同组成锚固复合体，锚固复合体直径D大小等同钻孔直径。复合弹性模量为Ea，其中锚固剂弹性模量为Em，锚杆弹性模量为Es，锚杆杆体直径为d，锚固长度为Lb，假定锚杆与锚固剂共同发生变形，孔壁上的剪应力为τ(u)，为剪切位移u的函数。假定弹性变形阶段锚固体材料符合胡克定律，在锚固段任意深度z处取锚固体微元段，其长度为dz，如图2所示。

CONSORT statement

(Begg C,et al.JAMA 1996;276:637-639.)

http://jama.ama-assn.org/cgi/content/summary/276/8/637

Article from journals with English abstracts only

Modi fied CONSORT statement

(Piaggio G,et al.JAMA 2006;295:1152-1160.)

Book—more than one author(list all authors if six or less,otherwise list first three followed by et al)

Systematic review of therapeutic interventions

QUOROM statement

http://jama.ama-assn.org/cgi/content/full/283/15/2008

http://www.thelancet.com/journals/lancet/article/

突出表现为长江上游特有鱼类（圆口铜鱼、长鳍吻鮈等）的种群数量下降明显，受威胁的鱼类数已占鱼类总数的27.6%；长江中下游“四大家鱼”等重要经济鱼类的种群规模显著下降；长江鱼类生物完整性指数多年来总体呈下降趋势，白鱀豚、白鲟、鲥鱼已功能性灭绝，长江江豚、中华鲟成为极危物种，2013年、2015年和2017年未监测到中华鲟自然繁殖行为。

PIIS0140-6736(99)04149-5/fulltext

每篇文献的关键词可以反映该文献的核心内容，通过对已发表文献的关键词出现频率的数量统计，可以归纳出一个领域的研究者所关心的主要内容和热点问题，有利于把握研究方向和发展趋势。利用可视化分析软件统计得出的文献关键词频率排名，如表6所示。

Diagnostic test performance study

高山有好水，贵州高原就以“奇山秀水”而闻名天下。发展乡村旅游，需要大量的饮用水和日常生活、工作用水。水资源非常珍贵，一旦污染破坏，想要恢复非常难，且要付出很大的代价。随着生态环境的恶劣，很多地表水被污染或干涸。一些乡村旅游开发的“农家乐”，直接建在湖边、河流旁，且向河内排泄脏水，导致水源无法饮用。

STARD statement

(Bossuyt PM,et al.Clin Chem 2003;49:1-6.)

http://www.clinchem.org/cgi/content/full/49/1/1

Systematic review of diagnostic tests

QUADAS statement

(BMC Med Res Method 2006;6(9).doi:10.1186/1471-2288-6-9.)http://www.biomedcentral.com/1471-2288/6/9

Systematic review of observational study

孔老一身后的宪兵于是手起刀落，从身后割断了捆扎的绳子，七八根断绳蛇一样落了一地。孔老一扎过绳子的地方由青转红，起了一道道血印子。

MOOSE statement

(Stroup DF,et al.JAMA 2000;283:2008-2012.)

(Moher D,et al.Lancet 1999;354:1896-1900.)

由于我们对教育学的复杂性质认识不够，就必定导致对教育学研究的不全面，造成对教育学各个方面的研究及其知识积累的不均衡。例如，很长一段时期，我们对教育学学科的认识深受凯洛夫教育思想的影响，赞同教育学是一门科学，要研究与总结教育的实践，去认识新生一代的教育规律。在其思想影响下，许多教育学者都十分重视对教育学规律的探索及其基本理论的阐释和系统科学知识的教学，却忽视教育价值和教育艺术的研究与教学，甚至有的老师不知道教育学还要研究教育价值和教育艺术。

Economic evaluations

CHEC criteria

(Evers S,et al.Int J Tech Assess Health Care 2005;21:240-245.)

http://journals.cambridge.org/action/displayAbstract?

fromPage=online&aid=292673

饲料和粪便中常规成分分析依据《饲料分析及饲料质量检测技术》[7]。采用范氏[8]洗涤纤维分析法测定ADF和NDF。

Letter of copyright transfer

We require a letter of copyright transfer signed by all named authors,stating that they have taken a signi ficant and active part in the preparation of the article,that they have read and approved the final version,and are willing to discuss it in detail.This is essential for the reviewing process to be completed.Possibly duplicative materials(i.e.,those containing substantially similar content or using the same or similar data)that have been previously published or are being considered elsewhere must be provided at the time of manuscript submission.

To conform with the Copyright Act of China,this letter must contain the following paragraph:

In consideration of Hepatobiliary&Pancreatic Diseases International reviewing and editing my(our)submission,the author(s)undersigned hereby transfer(s),assign(s),or otherwise conveys all copyright ownership to Hepatobiliary&Pancreatic Diseases International represent(s)that he(they)own(s)all rights in the material submitted.The author(s)further con firm(s)that the article is original,that it is not under consideration by another journal in any language,and that it has not been previously published,in whole or in part,in another journal in any language.There is no conflict of interests relevant to the study reported in this article.

For convenience potential author can download the form of the letter from our journal’s website.This assignment is to take effect only if the work is accepted for publication in Hepatobiliary&Pancreatic Diseases International.

These instructions can also be found on the journal’s website at www.hbpdint.com and may be copied by those intending to submit an article.

Letter of Copyright Transfer

Your name(printed)

Tel

Fax

Email

Corresponding author

Email

Manuscript entitled:

We have taken a signi ficant and active part in the preparation of the article,and we have read and approved the final version.We are willing to discuss it in detail.

In consideration of Hepatobiliary&Pancreatic Diseases International reviewing and editing my(our)submission,the author(s)undersigned hereby transfer(s),assign(s),or otherwise conveys all copyright ownership to Hepatobiliary&Pancreatic Diseases International represent(s)that he(they)own(s)all rights in the material submitted.The author(s)further con firm(s)that the article is original,that it is not under consideration by another journal in any language,and that it has not been previously published,in whole or in part,in another journal in any language.There is no conflict of interests relevant to the study reported in this article.

This assignment is to take effect only if the work is accepted for publication in Hepatobiliary&Pancreatic Diseases International.Authors’name(s)in order of appearance in the manuscript,signatures(date):

1.Full name(printed):

Abbreviated name in PubMed(printed):

Signed(handwritten):

Date:

2.Full name(printed):

Abbreviated name in PubMed(printed):

Signed(handwritten):

Date: