INTRODUCTION

Adhesive small bowel obstruction (SBO) is a common life-threatening complication of surgery or abdominal trauma in both pediatric and adult populations, typically caused by adhesions that form as a normal part of the healing process[1-3]. As a side effect of the inflammatory response required for healing to occur, adhesions form in tissues at and near the surgical repair within hours, due to the presence of collagen and scar tissue mediators.

Surgery is frequently cited as the primary cause of adhesive bowel obstruction; repeat surgery increases the risk of adhesion formation[4]. The financial cost per patient for adhesiolysis and bowel resection was$65955 and $114175, respectively, with 30-d hospital readmission rates of 12.3% and 18.1% in the United States in 2010[5]. The average hospital stay for cases of SBO surgery was 14.2 d, and for abdominal adhesiolysis was 8.4 d[5].

The present cost of a one-week course of CPA physical therapy is under $7000 in the United States(and is comparable in the United Kingdom). The therapy is performed in an outpatient setting; no hospitalization or surgery is required.

A large previously published clinical study that followed adult subjects 10 years post-surgery found that more than 30% of the surgical small bowel resection subjects underwent additional surgery due to adhesions within the study time frame[6]. In a prospective analysis of patients undergoing laparotomy who had previously had one or more abdominal operations, 93% (195/210)were found to have adhesions attributable to their prior surgery[1]. Patients with mesh inserted during surgery have been identified as having an increase in adhesion formation, leading to increased complexity of future surgical procedures[7-9].

Thus, adhesion related disease causes significant surgical efforts, hospital resources and comprises major expenditures each year. Additionally, there is a considerable negative impact on the patients’ quality of life (QOL).

In the absence of bowel ischemia, strangulation or perforation, current guidelines for the management of SBO are gastric decompression with suction, full strength gastrographin (in some institutions), and IV hydration for the first 24-72 h to see if the obstruction will resolve without surgery[10]. While sometimes effective in treating the current obstruction, this approach does not address the internal adhesions or the risk of subsequent bowel obstructions[11,12]. The only treatment currently available to reverse adhesive bowel obstructions is surgery, which frequently causes new adhesions. A number of surgical techniques, modifications, and adhesion preventing medications and barriers have been investigated, but no solution has been shown to significantly prevent the formation of adhesions to date[13-19]. Thus, any therapy that decreases the risk of bowel obstruction in the absence of surgery is of significant importance.

Manual physical therapy (mPT), a method of physiotherapy and rehabilitation, is used to treat patients with a wide variety of adhesive conditions including burns,adhesive capsulitis, radiculopathy, pain, infertility, and lessening of scars[20-30]. This therapy has shown promise in preventing adhesion formation in animal models[31,32].The Clear Passage Approach (CPA), a specialized mPT regimen, hypothesized to deform the adhesions that cause SBO episodes, has been demonstrated as effective in decreasing adhesions, pain, and improving QOL in subjects with recurrent SBO in case control and ef ficacy studies[33-35]. In pilot studies, independent radiologic reports showed that the therapy cleared bowel stricture and obstruction, obviating the need for planned laparotomy for adhesiolysis and SBO[36,33-35].

Surgery is often necessary in cases of bowel obstruction complicated by ischemia or caused by hernia or cancer, however surgery has not been shown to improve quality of life (QOL), reduce pain or recurrence rate in patients with adhesive SBO. Further, except as shown in pilot studies of CPA therapy, there is currently no other treatment available to patients with known adhesions who are currently not obstructed to reduce recurrence,pain or need for further surgery. In this study, we report on the use of the CPA, a manual physical therapy protocol, to treat abdominal and pelvic adhesions that cause SBO, and to improve the quality of life (QOL) of study subjects when compared to untreated subjects in a control arm.

Aim and hypothesis

The aim of the study is twofold: (1) To determine whether a manual physiotherapy can lower the rate of repeat SBO in patients who have undergone prior adhesive bowel obstructions and surgeries, and (2) to examine whether the therapy can improve the quality of life of these patients, using a validated test.

The hypothesis is that the manual physiotherapy treatment can decrease SBO recurrence and improve the self-reported quality of life in subjects with a history of adhesive SBO, compared to untreated control subjects.

MATERIALS AND METHODS

Eligibility criteria

Subjects in the retrospective CPA treatment arm were selected for inclusion in the study based upon medical history and completion of both a pre-treatment and post-treatment questionnaire. Only adult subjects were included in this study. Exclusion criteria included: BMI＞ 36, active infection, abnormal ovarian cysts, surgery within the last 90 d, and bleeding disorders. Each subject was provided with a written informed consent as is standard for the clinical practice. Subjects with a recent history of cancer were excluded from this study. A total of 103 subjects were treated at one of five private physical therapy clinics affiliated with Clear Passage between November 2012 and October 2015. All CPA therapists and af filiates completed 80 h practical training and evaluation course prior to becoming certified in the Clear Passage Approach. All subjects with follow up were eligible and included in the analysis.

Subjects in the control arm were recruited via website and online advertisements for the study. Inclusion criteria included: adult subjects who had experienced a partial or total bowel obstruction within the last two years.Exclusion criteria included: Cancer within the last 5 years,chemotherapy or radiation treatments in the last 10 years,current pregnancy, or prior treatment at Clear Passage.All study related activities were performed via the NIH Assessment Center (www.assessmentcenter.net) including screening, informed consent and all data collection. A total of 460 subjects were screened, with 281 subjects eligible and 260 completing the initial questionnaire; 6 subjects were removed from the control study due to having previously received CPA treatment, 117 subjects were lost to follow up, 1 subject was removed due to less than 50%of the follow up questionnaire being completed. A total of 136 subjects completed both questionnaires and were included in the analysis. The study diagram is shown in Figure 1. This study was approved by MaGil Institutional Review Board.

(1)镍铁中不含硅(Si)。采用高炉工艺和电炉工艺处理红土镍矿得到的粗镍铁合金中，硅含量一般为2%～4.5%，而采用新型富氧侧吹煤粉熔融还原技术，由于其属于熔池熔炼，温度控制在1 450～1 550 ℃，炉渣中FeO含量通常控制在5%～20%，SiO2会迅速与FeO氧化造渣，因此新工艺生产的镍铁水不含硅。不锈钢厂可以利用新工艺生产的镍铁中不含硅这一特点进行低硅铁水操作，可减少渣量，并降低造渣剂的消耗量。

Study design

This was a non-randomized controlled study comparing subjects with a history of SBO that underwent CPA treatment to that of untreated control subjects. The CPA treatment group included a retrospective chart review of subjects treated for adhesive disease with a history of SBO that had undergone standard clinic follow up. All subjects included in the treatment arm received treatment within private outpatient physical therapy clinics by therapists certified in the CPA. Subjects in a prospective untreated control arm, including those not treated with the CPA, were recruited for participation in a survey based observational data collection.

当天晚上，亚当的家人聚在一起为他办理后事。亚当的大哥斯坦利感到有些头痛，看见亚当的橱柜里有一瓶泰诺速效胶囊，就拿出一粒吃了，又给妻子吃了一粒。

Outcomes were measured via an observational manner using the validated paper based SBO Questionnaire (SBO-Q) using previously established quartiles[37].The SBO-Q was developed and validated to be used as a patient reported tool to quantify the experiences of patients with recurrent SBOs. The questionnaire is comprised of five domains and a pain rating section.Each domain measures a distinct aspect of QOL. The Diet domain assesses the diet of the subject from inability to tolerate any liquid to a normal solid food diet. The Pain domain reported pain throughout the body, with oral intake of food or liquid, and with bowel function.The Gastrointestinal (GI) Symptom domain quantifies symptoms often associated with SBO such as nausea,emesis, bowel spasm and constipation. The Medication domain reports the frequency of medications required to maintain bowel function. The QOL domain quantifies the amount of time off work, social activities and overall concern of the patient regarding their bowel function.These tend to be major lifetime concerns for many people who experience recurring bowel obstructions.

Subjects provided previous medical history and records; no radiologic evaluations were performed as a part of the study. Questionnaires were completed prior to treatment for the control measure. The posttreatment questionnaires were sent to the subjects 90 d post-treatment, with completion at 78-140 d posttreatment for the CPA treatment arm and 90-115 d for the control arm subjects.

Sample size calculation

For evaluating the power of our study, we made some simplifying assumptions. We assumed that differences in the 6 domain scores before and after treatment follow a normal distribution. For all but two of the SBO-Q domains we assumed that the mean difference was zero (i.e., no treatment effect), but for two domains we assumed that the treatment lowered the average domain score by 1 point. We assumed that the standard deviation of each difference was 2.5 points. We then simulated the power by looking at the proportion of times that both multiplicities adjusted two-sided P-values for the two domains where we assumed a treatment effect is less than 5%. When selecting a sample size of 100, this was the case in 82% of our simulations.Therefore, 100 patients in the pre- and post-treatment comparison result in at least 80% power to detect a significant difference of 1 point in the mean domain score of two domains. All computations were made in the statistical software R[38].

Treatment

Subjects treated with the CPA received manual therapy to areas of the body identified by the treating therapists as showing decrease mobility or function during the evaluation via palpation and range of motion tests.All subjects were evaluated from head to toe. In the case of these subjects the focus of the therapy was to the abdominopelvic viscera that demonstrated decreased mobility, hypothesized to be due to adhesions formed after surgery, trauma, or other tissue damage,therefore leading to SBO episodes. The majority of the therapy focused on treating abdominopelvic viscera that demonstrated decreased mobility with palpation.Treatment was administered in multiple hour sessions,which included up to four hours a day over the course of 5 d with the typical subject completing 20 h of treatment.The average number of treatment hours per subject was 22.6 ± 8.5 h with a range of 10-74 h; 75 of 103 subjects in CPA treatment group received 20 h of treatment.

In order to decrease adhesions, the CPA uses techniques from a variety of manual modalities to treat the subject in an individualized manner, focusing on each subjects’ areas of restriction and concern with the goal of deforming adhesions and increasing the mobility of adhered tissues and organs, working from the most superficial tissues to those deeper in the body. The therapy accomplishes this by the use of various sitespecific pressures across restrictive bands of adhered tissues and structures within the abdomen and pelvis,using a bimanual deep massage. The intent of the therapy is to detach and reverse the crosslinking that binds collagenous fibers together to form adhesions.The therapists work progressively deeper from the most super ficial tissues restoring mobility via myofascial release[39]. Adhesions within and between organs and interstitial spaces within the viscera were addressed using the Wurn technique[29,34] which is a bimanual soft tissue manipulation that can include a slow stretch to adhered areas within the abdomen and pelvis, previously shown to return patency to occluded fallopian tubes. The intent of this technique is to detach crosslinks that bind collagen fibers, thus shearing apart adhesions manually,in order to return the tissues to a more mobile, less adhered state. Toward the end of deep tissue work, CPA certified therapists may use visceral manipulation to increase organ motility[39]. The amount of force and time the force was applied to each area has the potential to be significant but was maintained within the tolerance of the subject in accordance with guidelines of the American Physical Therapy Association. Detailed clinical treatment records were maintained throughout the course of therapy.

系统采用GR-C工业机器人实现搬运功能。该机器人可在本机基础上增加机械元件和电气元件，通过指令编程实现相应的动作功能。比如CCD检测单元采用工业机器人将大工件搬运至材质检测单元、将小工件搬运至输送带；材质检测单元采用工业机器人搬运大工件；孔深检测单元采用机器人将大工件依次搬运至数控车床、加工中心、孔深检测工位、扫码单元或废料箱，将小工件直接搬运至扫码单元。

千克的出生地为法国。1799年，法国科学家提出了千克的最初定义，即1立方分米纯水在最大密度（温度约为4摄氏度）时的质量为1千克。很显然，最初的质量单位千克是由法国的长度单位米推导出来的。

基础组：常规护理，平扫完成，实施增强扫描时，检查患者身上是否携带金属类制品，和对患者临床信息，手术、药物禁忌，同时按照规定禁食8小时、禁水6小时。正式实施前，优选非离子型造影剂，经造影剂经高压注射器注入血量足、弹性高的绕静脉或者正中静脉血管。同时检查时，禁止带入手机，减少对磁场的影响，确保检查质量[2]。

Subject monitoring

Subjects enrolled in the control arm of the study were not monitored as this was an observational web-based study arm. Subjects included in the treatment arm were monitored daily for changes in pain, diet, bowel habits and overall well-being during their treatment as is standard practice. Adverse events were monitored by the treating therapists during the course of treatment and reviewed during the chart review process. There were no adverse events reported in the CPA treated group within the clinical data, or by follow up.

Disease scoring

The overall degree of adhesive disease was determined using a clinic generated disease scoring table that takes into account all qualitative and quantitative measures performed during the initial evaluation and post treatment discharge assessment. The degree of impact on a subject’s quality of life for range of motion was determined using multiple resources, as well as the extensive experience of the therapists. Multiple other standard physiotherapy tests were also performed and included in the assessment for disease score[40-44]. Supplemental Table 1 contains the disease scoring protocol in which the score is expressed as a decimal in which 0 represents no disease or impact on overall function and 1 is severely impacted.

Statistical analysis

We used χ2 tests and t-tests for the analysis comparing the demographic and medical variables between the treated and control group.

For analyzing the multivariate responses from the SBO-Q we used the minimum P-value based on a paired t-statistic for each survey question as the test statistic for the overall and the domain hypotheses[45]. The raw and multiplicity adjusted P-values displayed in tables refer to testing the null hypothesis that the mean difference between the initial and follow-up survey equals 0. Since there are 6 domains for which we tested for a mean difference, we used multiplicity adjusted P-values to adjust the raw P-values and account for the fact that we are testing 6 hypotheses simultaneously. For a particular domain, a significant difference in the mean domain score can be concluded when the corresponding multiplicity adjusted domain P-value is less than 0.05.Using the multiplicity adjusted P-values (computed via the Bonferroni correction) will control the overall (familywise)error rate at 5%. Similarly, the multiplicity adjusted P-values for each survey question account for the fact that we are testing 37 hypotheses comparing mean differences simultaneously, one for each question. For any given survey question, a multiplicity adjusted P-value less than 0.05 implies a significant difference in the mean score, controlling the overall rate of Type I errors at 5%when testing these 37 hypotheses simultaneously.

李兰芬刚嫁到张家时，张全文一贫如洗。“分家分到了一只桶、一个锅、一根扁担，然后就没有了。”家徒四壁，加上两个能吃能闹的儿子，奋斗就靠夫妻的两双手，难免会有不满、疲惫的时候。但在张伦的印象中，母亲一直是很隐忍的人，从小到大，和父亲几乎都没有吵过架。

The statistical package R (R Foundation for Statistical Computing, Vienna, Austria) was used for all statistical analyses.

RESULTS

A total of 103 CPA treated subjects and 136 untreated control subjects were included in the analysis. Demographics for study subjects are located in Table 1 and number of prior surgeries and bowel obstructions are located in Table 2. Subjects in the CPA treatment group were significantly older, and the total numbers of prior surgeries, partial SBOs, and years impacted with bowel symptoms were much higher than that of the control group. There were 46.2% male subjects in the control group and 32% male subjects in the CPA treated group (P = 0.0853). The average age of subjects in the control group was 36.4 ± 12.5 years and 54.5 ±15.7 years for the CPA treated group (P ＜ 0.001); the average number of prior surgeries in the control is 2.07± 1.29 as compared to 4.56 ± 2.86 for the CPA treated(P = 0.0001). The average number of prior partial SBOs in the control group was 1.88 ± 1.60 and 3.97 ± 5.09 in the CPA treated group (P = 0.0001). The number of total SBO was 2.17 ± 1.85 for the control group and 1.68± 7.95 for the CPA treated group (P = 0.4894). The number of years the subjects reported bowel symptoms impacted their lives was 5.5 ± 7.2 for the control group and 10.7 ± 11.2 for the CPA treated group (P ＜ 0.001).

水肥管理是油茶苗木栽培管理中非常重要一部分，经过施肥，可以对油茶的生长具有重要作用。控制好水肥才能够更好的保证油茶更好的生长，避免因为营养不足影响苗木生长。

Rates of recurrent SBO

Surgery is often cited as a primary cause of recurrent SBO due to the formation of post-operative adhesions. If a non-invasive outpatient therapy can decrease recurrent SBO and reduce the need for additional surgeries, it can improve quality of life for patients, with lower risk and decreased cost.

The availability of the therapy is presently limited to private outpatient clinics in the United States and United Kingdom where therapists have been fully trained and cert ified in the CPA.

SBO-Q analysis

For both the control and CPA group we tested the null hypothesis that for each of the 6 domains the mean domain score the first time the survey was administered was equal to the mean domain score the second time the survey was administered 90 d later. The alternative hypothesis was that there was a significant difference in the mean domain score between the initial and followup administration of the survey for at least one domain.Missing data from any question/subject was removed from the overall analysis.

For the control group data, despite the fact that no intervention took place between the two times the survey was administered, Table 3 shows a significant difference(multiplicity adjusted P ＜ 0.05) in mean domain scores for the Pain and GI Symptoms domain. However, the lower bounds of a corresponding confidence interval for the mean difference in domain scores are close to zero (0.02 and 0.05, respectively), indicating that, while statistically significant, the actual improvement may be very small.

模型主要的作用是处理不同用户的请求，对于动态化的网络系统来说，其是指操作信息库的接口部分，也可将其归纳到功能辅助类别中，帮助控制器更好的工作。模型板块的设计也是重要环节，共包含三部分，即信息库驱动的初始化、信息库的crud实践操作与映射信息表。PHP框架模型层运用的是三层结构模式，为了能够支持不同种类信息库以便进一步实现深入拓展及转移，PHP框架应使用PDO套件，该套件支持主流信息库驱动。

A further analysis of the individual survey questions shows that within the Pain domain, General, Lower GI,BM and Eating pain improved significantly between the initial and follow-up survey. However, note the small lower bounds for the corresponding con fidence intervals for the mean difference, indicating very small changes except perhaps for BM and General pain. The significant improvement in those two could reflect a time-effect, the perceived pain lessening over time. Similarly, the three significant differences for individual questions in the GI Symptoms domains all have very small lower bounds of corresponding con fidence intervals. For all other domains and all other individual survey questions within domains no significant differences emerged (multiplicity adjusted P-values ＞ 0.05). The diet domain had multiplicity adjusted P = 0.425, the Medication domain P = 0.804,and the QOL domain P = 0.126, all indicating no major changes in symptoms over the three-month period studied.

For the CPA group, Table 4 shows significant differences for all domains (multiplicity adjusted P-value ＜ 0.05)except for the Medication domain (multiplicity adjustedP-value = 0.176). The domain confidence intervals indicate that the mean difference in the average Diet and Quality of Life score falls somewhere in between 0.5 and 1.0 on the 5-point scale, which is a rather large average effect. (For comparison, in the control group, no significant differences were reported for these two domains). Further,the difference in the average Pain Severity score was significant, ranging from 1.07 to 1.95. (For the control group, there was no significant difference.)

Overall, in the CPA group 29 out of 37 survey questions showed a significant difference (in fact, improvement), compared to just 7 in the control group.Judging by the confidence intervals (CIs), some of the strongest improvements were seen in the Pain, QOL, and Diet domains. In the Pain Domain, notable improvements occurred for the questions “Experience of pain in general”(CI: 0.43-1.34), “Experience pain in the upper GI region”(CI: 0.41-1.29), “Recent Maximum Pain” (CI: 1.62-3.78)and “Duration of Pain” (CI: 0.61-1.82).

机器人在室内运动模型可以如图2所示的，采样周期为T，机器人在k-1时刻所在的估计位置在点pk-1处，后验估计状态为假设机器人沿着弧s在k时刻运动到位置为pk处，在pk处的先验估计状态为则弧长弧s对应的圆心为o，圆心角角度 Δψ=Tdψk-1，圆弧的半径为r=s/Δψ，直线长度 l=2rsin（Δψ/2），该直线与x轴夹角为可推导得到系统的状态方程为：

There is a place for a multi-disciplinary approach to a vexing problem for surgeons - the recurrence of adhesions and SBO following abdominal surgery or pelvic surgery. We hope to be able to quantify further the degree to which CPA can decrease the recurrence of SBO, and the need for repeat surgeries.A prospective controlled study with closely matched study groups could be performed with the CPA method vs sham physiotherapy.

一位北京协和医学院的护士看到了患儿并和她的母亲说起了这个孩子。护士的母亲在家很孤单，因为她自己的孩子们都已长大成人或是在校读书，所以她想收养一个女婴为伴。

When the total number of subjects per SBO-Q domain are assessed for both questionnaires for the quartiles indicating the degree of impact (normal, mild, moderate and severe) it was observed that the general trend demonstrated more subjects reporting experiences corresponding to no impact or normal for the quartiles in the CPA treatment group than the control group (Table 5).The significance observed in the individual question score analysis is also observed in this representation of the data, showing the clinical significance of these changes in the CPA treated group.

Trunk range of motion

All CPA treated subjects underwent a comprehensive physical therapy initial evaluation that included measurements for range of motion (ROM). It has been previously demonstrated that a significant improvement in ROM in the trunk was observed in patients with a history of SBO and may be a positive predictor for outcome.Included in these measurements are: trunk flexion; trunk extension; left and right side bending; left and right trunk rotation[40,42–44].

Every subject who presented with decreased ROM demonstrated improvement for at least one of the measurements presented in Table 6. Furthermore, 31.47% of total measurements were within the normal range after CPA treatment compared to 19.74% before treatment.Although not all subjects had a normal ROM for all measures after treatment, all subjects demonstrated overall improvements.

Statistical analysis of changes showed a significant increase in the mean ROM after treatment compared to before for all six measures (multiplicity adjusted P-values＜ 0.05).

Patients with a history of SBO and surgery often presented with a kyphotic posture; we surmised this was due to the pull of abdominal adhesions, creating a forward flexion of the trunk. The improvement in trunk extension following CPA treatment suggests that adhesions in the abdomen and pelvis that prevented the subject from bending backwards or standing upright prior to therapy diminished enough to show significant improvement in trunk extension following the manual treatment. The improvements in side bending and rotation also suggest that decreasing adhesions in the abdomen and pelvis allowed improved trunk ROM. These findings indicate that improvements in trunk ROM measurements may be suitable as a predictor for degree of adhesion deformation post CPA treatment.

Disease scoring

The observations made by the therapists at the initial evaluation and after CPA treatment were utilized to generate an objective numerical value for analysis of the overall state of the adhesive disease of the treated subjects. This numerical score takes into account the entire patient - assessed from head to toe, and includes ROM, organ motility, standard physical therapy tests,posture and tissue response with a range from 0 (no disease or deficiencies) to 1.0 (maximum disease)(supplemental Table 1). A total of 101 subjects in the CPA treated group were included in the assessment; results showed significant improvement in the full body disease score. Prior to CPA treatment the average disease score was 0.65 ± 0.11 (range 0.37-0.95) compared to post CPA treatment 0.29 ± 0.10 (range 0.1-0.53) (P ＜0.001). This measure correlates well with both the ROM measures (Table 6 and the changes observed in the quartiles post CPA treatment in Table 5).

DISCUSSION

It is widely accepted that the adhesions that cause SBO and symptomology in subjects are often caused due to prior abdominal or pelvic surgery[10,46]. This study is the first controlled study of a specific physical therapy protocol known as the Clear Passage Approach (CPA)in subjects with a history of SBO. The results of this study are very similar to those reported in an earlier uncontrolled efficacy study and case reports using the CPA to treat subjects with recurring SBO[35]. In all measures, the subjects treated with the CPA experienced significant improvements as compared to experiences before CPA treatment and when compared to untreated controls. Manual physical therapy can provide adjunct therapy for known adhesions where there is no other available therapy proven to decrease recurrent SBO or to treat pain associated with adhesive disease. Unlike surgical procedures, adhesions do not appear to occur after treatment with the CPA[28].

Because treatment group participants had more complex histories and symptoms, their improvements likely had more of an impact on daily function than subjects in the control group. The results from this study suggest that the CPA can be used to treat adhesions and scar adherence safely in the recurrent SBO subject population, demonstrating significant improvements in overall pain, severity of pain, QOL and number of episodes of SBO as compared to untreated subjects.Further, subjects who were previously concerned about having another SBO episode reported a significant decrease in that concern three months after treatment.In addition, the cost savings from using a relatively inexpensive outpatient treatment in place of surgery to prevent future obstruction, hospitalization and surgery is worthy of consideration.

Based upon changes in range of motion and disease scores, it is inferred that tissue and organ mobility was improved as the subjects demonstrated an increased range of motion in active movement tests. Improvements in range of motion allowed subjects to perform daily tasks more easily and contributed positively to their overall QOL.

2 ten Broek RP, Issa Y, van Santbrink EJ, Bouvy ND, Kruitwagen RF, Jeekel J, Bakkum EA, Rovers MM, van Goor H. Burden of adhesions in abdominal and pelvic surgery: systematic review and met-analysis. BMJ 2013; 347: f5588 [PMID: 24092941 DOI:10.1136/bmj.f5588]

5 HCUPnet: A tool for identifying, tracking, and analyzing national hospital statistics. 2012; Available from: URL: http://hcupnet.ahrq.gov/HCUPnet.jsp?Id=6D36343307A90AD9Form=SelLAYJS=YA ction=%3E%3ENext%3E%3E_LAY=Researcher

Research background

Manual physiotherapy (mPT), called “manual physical therapy” in the United States, has been used to treat a wide variety of adhesive conditions including burns, adhesive capsulitis, radiculopathy, pain and the lessening of scars. In pilot studies, independent radiologic reports showed that the Clear Passage Approach (CPA), a specialized mPT performed in an outpatient setting,cleared bowel stricture and obstruction, obviating the need for planned surgical adhesiolysis and bowel resection. In case control and efficacy studies, CPA demonstrated effectiveness decreasing adhesions and pain, and improving quality of life (QOL) in subjects with recurrent small bowel obstruction (SBO).

All subjects at the 90-d follow up questionnaire were queried regarding the numbers of bowel obstructions,hospitalization, and surgery for SBO experienced.There were differences between the groups, with the CPA treated group reporting fewer total number of obstructions, hospitalizations and surgeries. A total of 124 control and 103 CPA treated subjects responded to the questions. 21.77% of the control group subjects and 8.74% of the CPA group subjects experienced a partial bowel obstruction between the two questionnaires (P =0.0076), 14.52% of control group subjects and 0.97%of CPA group subjects reported a total bowel obstruction(P = 0.0003), 5.65% of control group subjects and 1.94% of CPA group subjects reported undergoing surgery for a bowel obstruction (P = 0.1548). The differences between untreated and treated patients at follow up would naturally extrapolate into a sizable decrease in cost, due to avoiding repeat SBO-related hospitalizations and surgeries.

ARTICLE HIGHLIGHTS

Research motivation

Adhesions that form after surgery present major problems for physicians and their patients. Surgeons note that adhesion barriers and gels are not always effective at preventing recurrent adhesions. The opportunity to delay or prevent post-surgical adhesions that can cause pain and recurring bowel obstruction is profound for patients. Many people live in fear that another major surgery or death could occur at any time, due to a recurrent obstruction.

Research objectives

The study has two main objectives: (1) To determine whether a manual physiotherapy can lower the rate of repeat SBO in patients who have undergone prior adhesive bowel obstructions and surgeries; and (2) to examine whether the therapy can improve the quality of life of these patients, using a validated test.

她感觉到那么茫然和无助，她想要有钱，可以给顾青弟弟治病，可以让顾青不用熬夜兼职，可以换一个带厨房带空调的房子，但她也才大学毕业，手拿一两千的工资，在这个城市营营求生。

Research methods

This is a controlled phase two study in which 103 subjects with a history of recurrent adhesive SBO were treated with a manual physical therapy called the CPA. The focus of the therapy was to decrease adhesive crosslinking in abdominopelvic viscera. Pre- and post-therapy data measured recurring obstructions and quality of life using a validated test sent 90 d after therapy.Results were compared to 136 untreated control subjects who underwent the same measurements, but who did not receive any therapy. Until this method was developed, physical therapy has never been investigated as a course to treat recurring SBO.

Research results

Despite histories of more prior hospitalizations, obstructions, surgeries, and years impacted by bowel issues, the 103 CPA-treated subjects reported a significantly lower rate of repeat SBO than 136 untreated controls (total obstructions P = 0.0003; partial obstructions P = 0.0076). Subjects treated with the therapy demonstrated significant improvements in five of six total domains in the validated Small Bowel Obstruction Questionnaire (SBO-Q). Domains of diet, pain, gastrointestinal (GI) symptoms, quality of life (QOL) and pain severity when compared to post CPA treatment were sign ificantly improved (P ＜ 0.0001).The medication domain was not changed in the CPA treated group (P = 0.176).

Numerous studies examine the use of mPT to decrease adhesions and pain, and to improve function for conditions in various parts of the body. Pilot studies that examine the use of CPA include independent radiographs of cleared bowel obstruction. In a 10-year retrospective study of using CPA to treat adhesion-related female infertility (n = 1392), CPA opened blocked fallopian tubes in 60.85% (143/235) of women diagnosed with total tubal occlusion. In a recent study, mPT was shown to disrupt bowel adhesions in a rat model.This is the first controlled study of using a manual physiotherapy to decrease adhesions in the bowel.

能入选特种部队的人开始都感觉自己特有本事，但不是每名队员都能完全承受训练，陆续有人调离、转到后勤甚至退伍。开始1000人的新兵队伍，几个月后只剩下不到500人的作战人员。

Research conclusions

A manual physiotherapy sign ificantly improved quality of life and significantly decreased the rate of re-occlusion for patients with a history of SBO. Performed in an outpatient setting, the non-invasive therapy significantly reduced repeat obstructions. In addition, the physical therapy has a much lower risk and cost than hospitalization or surgery.

The study proposes that manual physiotherapy, which is commonly used to decrease adhesions in a variety of conditions, may be useful to decrease adhesions in the bowel. As such, it may delay or prevent recurring SBO.

This study noted that: (1) Post-surgical adhesions are frequently cited as the primary cause of SBO; (2) average costs in the United States for adhesiolysis and SBO are $65955 and $114175, respectively; (3) average hospital stays for adhesiolysis and SBO are 8.4 d and 14.2 d, respectively; (4)costs for a novel non-surgical physiotherapy to address adhesions and SBO are less than $7000; (5) Subjects treated with the therapy reported a sign ificantly lower rate of repeat SBO than the untreated controls (total obstructions P =0.0003; partial obstructions P = 0.0076); (6) subjects treated with the therapy demonstrated significant improvements in five of six total domains in the validated SBO-Q; (7) statistical analysis showed a significant increase in all six measures of trunk range of motion ( flexion, extension, left and right side bending, left and right rotation.)

A manual physiotherapy sign ificantly decreased the rate of recurrent small bowel obstruction (SBO) and improved quality of life for patients with a history of prior SBO. Based on the decreased number of recurring obstructions and the measurable improvements in trunk range of motion, this manual physiotherapy can sign ificantly improve outcomes and quality of life for patients who undergo abdominal or pelvic surgery to treat adhesions or SBO.

This study proposes the use of a specialized manual physiotherapy, the CPA, to delay or prevent recurring SBO. This study con firmed and quantified hypotheses from earlier pilot studies that CPA could increase QOL, delay or prevent recurring SBO, and delay or obviate the need for additional surgery for patients with recurring SBO, with less risk and a lower cost than the present model. The major implication for clinical practice is that physicians,who are often stymied by the frequent recurrence of adhesions and SBO following abdominal surgery or resection, now have a less risky and less costly alternative to repeat surgery.

Research perspectives

Patients who have undergone the significant trauma of SBO accompanied by long hospital stays (average 14.2 d[5]), followed by invasive surgeries and recovery from those events have significant “QOL” concerns afterwards.With regard to the QOL domain, some noteworthy large differences between the initial and follow-up survey were observed for the question “How often the subject worries about another SBO” (CI: 0.78-1.85), “How often the subject was unable to perform daily functions” (CI:0.53-1.45) and “How often the subject was unable to attend social events”, (CI: 0.36-1.21). Related to QOLbut analyzed under the Diet domain, the question about“The ability to eat anything” also showed some large improvements (CI: 0.44-1.53).

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The limitations of this study include the lack of randomization and sham treatment group. A sham treatment is challenging to accomplish in a study such as this where the treatment is 20 h of manual therapy over the course of one week. Indirect measures used to assess adhesions in the subjects including improvement in self-reported symptoms; ROM and objective disease scoring were used as outcome measures. While these measures are indirect,all correlated well with the post CPA treatment experiences and the decreased number of SBOs and surgeries in the treatment group, compared to the control group.

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Today when a patient is discharged after non-surgical(or surgical) management of adhesive SBO, there is no therapy that can be prescribed to help reduce recurrence.Further, the quality of life for patients who have undergone SBO, with or without surgery, is often greatly compromised. Repeat surgery for SBO is widely regarded as a primary cause of recurring SBO. This technique appears to delay or obviate surgery for many patients who have undergone the trauma of SBO, at a fraction of the cost of surgery. It offers a therapy where none is currently available. The CPA therapy appears to be a viable conservative option for patients who previously were told that there was nothing that they could do to reduce their chances of recurrent SBO.

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