INTRODUCTION

Recent research shows that the occurrence of myopia is on a rising trend[1-3]. With the increasing prevalence of myopia, high myopia (HM) is becoming more commonly widespread as well[4-6]. The elongation of the eye axis in high myopia typically results in peripapillary atrophy, disc tilt,sub-foveal choroidal thinning, scleral thinning, and deformed eye structure[7-10]. Koh et al[11] showed that disc tilt, posterior staphyloma, and chorioretinal atrophy were associated with reduced visual acuity and that myopic-related changes of the optic disc and macula are commonly found in HM eyes,even at young ages. Accumulating evidence shows that age is another risk factor for myopic maculopathy, in which some of these changes are associated with reduced central visual function[12-15]. However, changes in the location of the fovea should not be overlooked, as it has not been reported yet whether the shift in the posterior pole affects the location of the fovea.

In this study, we analyze the effect of different ages and axial lengths (AL) on the foveal position by evaluating the position of the fovea relative to the center of the optic nerve head(ONH). With the ONH as the reference point, three indices were measured: the distance between the fovea and the ONH center (DFO), the vertical distance between the fovea and the horizontal line pass of the ONH center (VDFO), and the horizontal distance between the fovea and the vertical line pass of the ONH center (HDFO). These measurements, conducted by Topcon Atlantis DRI-OCT, were used to investigate the relationship between age and AL.

SUBJECTS AND METHODS

Subjects Patients with HM were consecutively recruited from the Third Affiliated Hospital of Nanchang University between May 2016 and February 2017. HM was defined as a lens correction of more than 6.0 diopters or an AL greater than 26 mm. In this study, subjects with an AL less than 26 mm were additionally included if they had a largecorneal curvature, as it results in a correction of more than 6.0 diopters. Exclusion criteria comprised of other ocular diseases that affected the position of the fovea. A total of 96 cases (186 eyes) were selected for this study: 62 females (123 eyes), 34 males (63 eyes), right eyes (94 eyes), and left eyes (92 eyes).The age range was from 7 to 81 (41.53±18.14) years old,and AL from 24.75 to 36.10 (28.76±2.61) mm. Participants obtained oral informed consent and not received any stipend.The study protocol was approved by the Institutional Review Board of the Third Affiliated Hospital of Nanchang University and complied with the tenets of the Declaration of Helsinki.

Table 1 Comparison of the foveal position in different age groups

aStatistical significance compared with group A2.

Parameters Group A1 (n=26) Group A2 (n=36) Group A3 (n=90) F P Age (y) 14.89±2.65 31.05±7.30 54.54±9.32 VDFO (μm) 907±1147 680±365 1012±561a 3.21 0.04 HDFO (μm) 4896±433 4907±731 4948±636 0.10 0.90 DFO (μm) 5147±651 4964±702 5029±745 0.46 0.62

Table 2 Comparison of AL to the horizontal and vertical changes in the foveal position

aStatistical significance with AL1.

Parameters AL1 (n=24) AL2 (n=49) AL3 (n=38) AL4 (n=73) F P AL (mm) 25.52±0.35 27.07±0.51 28.80±0.50 32.13±1.63 VDFO (μm) 703±672 889±743a 849±465a 1217±759a 3.12 0.02 HDFO (μm) 4871±354 4851±470 4883±482 5013±925 0.48 0.69 DFO (μm) 4895±391 4989±576 5002±468 5112±1095 0.37 0.76

Position of the Fovea Topcon DRI-OCT Atlantis was utilized, using the 12 mm×9 mm scan mode to capture OCT images. We used three indices to accurately determine the position of the fovea. As seen in Figure 1, the position of the fovea and the ONH was determined using HDFO (long violet line), VDFO (short violet line), and the calculation of DFO(DFO2=HDFO2-VDFO2).

Refractive Error Patients (＜18 years of age) were examined retinoscopically following an instillation of three drops of tropicamide 0.5%, which were instilled at 5-min intervals.After the instillation of the third drop (＞30min), subjective refraction was performed. Patients ＞18 years of age were examined directly using subjective refraction.

形声字是由形符和声符构成，在对外汉字教学研究中，针对形符的研究数量较多。出现这种现象的原因是形符表义功能的优势比较明显。康加深(1993)对形声字表义状况做过统计，其统计结果是：85.92%的形声字其形符与意义有一定的联系。虽然形符是具有表义功能的，但是不是指形符能够表示形声字的具体意义，而是表示类属于同一个语义场，即具有相同形符的字之间存在着一定的联系，有着共同的属性。如，“热、煎、煮、熟”都具有相同的形符“灬”，此形符古同火，表示火的意思，而这四个字的意思都跟火有关，这就是形符表义功能的体现。

Analysis of the age groups indicated that from the differences in DFO, HDFO, and VDFO, positional changes in the fovea were not obvious in ages under 40y. But after the age of 40, vertical changes were evident. Figure 2B and 2C show horizontal distribution (with 500 μm as the center of the distribution) and vertical changes under 1000 μm in ages below 40y. Figure 2D shows that the location of the fovea shifted to be around 1000 μm away from the vertical distance, increasing the range of the horizontal distribution. In addition, there was no large horizontal change following the elongation of the eye axis. After an AL greater than 26 mm,the fovea started changing towards the vertical direction. As demonstrated in Figure 3, HM eyes with an AL within 26 mm had a VDFO of 0 to 1000 μm and a HDFO of around 5000 μm(Figure 3A). Following the lengthening of the eye axis, the fovea was first distributed in the horizontal direction (Figure 3B),and then distributed in the vertical direction (Figure 3C). When the AL was greater than 30 mm, the distribution of VDFO was between 0 to 2000 μm and the distribution of HDFO was between 4000 to 6000 μm. Correlation analyses demonstrate that VDFO is associated with age and AL, while HDFO and DFO are not correlated with age and AL.

Analysis of the Relationship among VDFO, HDFO, DFO,Age, and AL VDFO is associated with age and AL, while HDFO and DFO are not correlated with age and AL (Table 3).

关于翻译的研究，从“信、达、雅”到后来的“三美”理论，都有他们的必要性。但是总的来说，不论是什么作品的翻译，都不仅仅需要传达字面的意思，还应该根据不同国家的文化背景做适当的调整。对于英文电影字幕翻译，有它自己的特色。字幕是为了让观影者了解电影情节，有文化交际的功能。与此同时，字幕翻译的语言一般比较大众化，在逻辑性与艺术性等方面有着特殊的要求。

Figure 1 The distance between the fovea and the ONH center(DFO), the vertical distance between the fovea and the horizontal line pass of the ONH center (VDFO, short violet line), and the horizontal distance between the fovea and the vertical line pass of the ONH center (HDFO, long violet line).

RESULTS

Effect of Axial Length on the Foveal Position The VDFO of AL2, AL3, and AL4 was significantly larger compared to AL1, as the difference between the groups was statistically significant. Yet, there was no statistical significance within groups AL2, AL3, and AL4. For HDFO and DFO, there was no statistical significance within the four groups (AL1, AL2,AL3, AL4) (Table 2). The location of the fovea with different ALs is presented in Figure 3.

东山是宜昌城的制高点。占领东山，就可以起到压制全城的作用。日军占领宜昌后，为了在东山建立永久性军事工程，拆除了东山草堂，毁坏森林绿地，修建雕楼暗堡，把一处好端端的风景名胜破坏贻尽。

Effect of Age on the Foveal Position In the HDFO and DFO comparison, groups A1, A2, and A3 were not statistically significant. However, there was a statistically significant difference within the VDFO comparison. Compared to groups A1 and A2, the VDFO of group A3 was significantly larger(Table 1). The location of the fovea in different age groups is shown in Figure 2.

Statistical Analysis Descriptive analyses of the data were undertaken by using SPSS 16.0 software (SPSS, Inc., Chicago,IL, USA). A one-way analysis of variance (ANOVA) and a correlation analysis of the statistical methods were used. A P value of less than 5% was considered statistically significant.

Figure 2 Changes in the foveal position in different age groups(zero as the center of ONH) A: The distribution of the fovea location of HM; B: The distribution of the fovea location of HM in group A1; C: The distribution of the fovea location of HM in group A2; D: The distribution of the fovea location of HM in group A3.

Figure 3 Changes in the foveal position with different AL (zero as the center of ONH) A: The distribution of the fovea location of HM in group AL1; B: The distribution of the fovea location of HM in group AL2; C: The distribution of the fovea location of HM in group AL3; D: The distribution of the fovea location of HM in group AL4.

Table 3 The correlation among VDFO, HDFO, DFO, age, and AL

Parameters VDFO HDFO DFO Pearson P Pearson P Pearson P Age 0.21 ＜0.01 0.02 0.74 -0.02 0.78 AL 0.23 ＜0.01 0.16 0.06 0.10 0.27

DISCUSSION

HM, along with the elongation of the eye axis and the formation of posterior scleral staphyloma, leads to the irregular expansion of the posterior pole. In the posterior scleral staphyloma of a HM eye, the tilting of the optic disc often leads to morphological changes in the macula. However, it has been rarely reported whether this affects the position of the fovea. To better determine the positional changes of the fovea,this study used DRI-OCT (with the ONH as a reference point)to accurately locate the position of the fovea with VDFO,HDFO, and DFO. We also categorized different ages and AL to undergo group analysis.

Axial Length Measurement IOL Master (Carl Zeiss Meditec, USA) was used to measure the AL for 5 times. The average was taken, and if there was a deviation within the 5 measurements, the datum was not used in the study.

In a normal eye, the marginal distance from the fovea to the temporal side of the ONH (DFO) is always consistent[16]. In a group with a refractive power of 0.9±1.7 diopter of spherical power (DS), the average DFO was 4.78 mm (4.69-4.86 mm);in a group of -9±1.7 DS, the average DFO was 4.62 mm (4.22-5.04 mm)[17]. Yet, the average DFO in a high myopic eye is 4.95±0.40 mm (4.34-6.16 mm), which is about 44.3% greater than 5 mm[16-17]. In this study, the distance analyzed (dMO)was calculated from the fovea to the center of the ONH, not the temporal side of the ONH. The average DFO in an HM eye was 5032±716 μm and ranged from 1800 to 7747 μm,with 25% of the eyes under 4651 μm, 50% under 5000 μm,and 75% under 5385 μm. There were 4 eyes (2.9%) under 4000 μm,65 eyes (46.7%) between 4000-5000 μm, 61 eyes (43.9%)between 5000-6000 μm, and 9 eyes (6.5%) above 6000 μm.

赵五娘的第一个愿望是与新婚丈夫蔡伯喈厮守，这个愿望的发送者是丈夫，接受者则是夫妻二人。这个愿望的帮助者有丈夫和蔡母。需要注意的是，这两人的帮助作用有着微妙的不同。丈夫和赵五娘的愿望是一致的，二人都眷恋和美的夫妻生活，不愿意分离。蔡母的态度与赵五娘是一致的，即不愿蔡伯喈去参加科举考试，而希望他留在家里。但是蔡母的出发点并不是赞成夫妻二人缠绵，“我到不合娶媳妇与孩儿，只得六十日，便把我孩儿都瘦了”⑥；她只是希望儿子留在家中照顾自己和蔡父。虽说另有心思，但蔡母的态度客观上有利于赵五娘愿望的实现。

Grouping Method Age groups (A1, A2, and A3) were divided by age range: ≤18y, ＞18 to ≤40y, and ＞40y, respectively. AL groups (AL1, AL2, AL3, AL4) were determined by length:≤26 mm, 26.01 mm to ≤28 mm, 28.01 mm to ≤30 mm, and＞30 mm, respectively.

漫长的暴风骤雨之后，被男人浸润透了的伍亦苒满足而又嗔怪地说，怕了你了，像一个饥饿的孩子，房间都订好了，却还要在这里。

马克思主义与马克思主义大众化研究学科是“源”与“流”的关系。从学科维度考量，马克思主义大众化研究学科是马克思主义学科发展所驱，马克思主义的实践性、社会性、历史性与主体性等特征，决定马克思主义必然大众化。从政治维度考量，马克思主义的阶级属性与理论使命，也决定马克思主义必然大众化。因此，马克思主义大众化研究学科的建设与发展，必受到真理性与价值性的促进或制约，真理性体现学术发展的需要，价值性则体现巩固意识形态的需要。马克思主义大众化研究学科的真理性与政治性特征，决定了马克思主义大众化研究学科必须要以马克思主义作为根本支撑，同时还必须要借助其他学科作为重要支撑。

An additional study by one of the authors further compared the HDFO and VDFO of HM and pathological myopia.Analysis of the data showed that the HDFO and VDFO of HM were 5046±719 μm and 966±603 μm, respectively.There was no statistical significance between the horizontal distances (HDFO), despite a statistically significant difference in the vertical distances (VDFO). This highly suggests that the position of the fovea shifts in the vertical direction in the progression of high myopia to pathological myopia. Some researchers have used the same DFO parameters, and found that DFO, AL, and optic disc tilt are related[18-20]. Other researchers have also used the distance between the fovea to the ONH or the side distance of the myopic arc to analyze the morphological changes in the retina of HM eyes[21-22]. Although other studies use different measurement techniques, these data demonstrate that the distance from the optic disc to the position of the fovea is elongated compared to normal eyes, simple high myopia, and pathological myopia in HM.

The current study does have some limitations, such as a small number of subjects. We had also excluded some subjects with ocular diseases that affected the position of the fovea. Thus,the sample population may not have been truly representative of the general HM population. Another investigation with more subjects may be needed in the future. In addition, some confounding factors, such as other factors affecting the foveal position, may not have been controlled and therefore we cannot completely exclude the uncontrolled confounders. However,with the increasing prevalence of high myopia, we hope that our measurements and findings will enhance the understanding of HM and advance research on this disease. In summary, the position of the fovea shifted mainly in the vertical direction as a result of age and the elongation of the eye axis in HM eyes.Our results clearly show that VDFO is associated with age and AL, while HDFO and DFO are not correlated with age and AL.The foveal position changed mainly in the vertical direction along with factors of age and AL in high myopic eyes.

ACKNOWLEDGEMENTS

We would like to acknowledge Peng Huang (Department of Epidemiology, School of Public Health, Nanchang University,Jiangxi Province, China) for conducting the statistical analyses.

Foundations: Supported by the Research and Development Project of Science and Technology of the Jiangxi Province(No.20171BBG70100); the Ophthalmic Innovation Project of Nanchang City (No.2016114).

Conflicts of Interest: Zhang Q, None; Chen KK, None; Liu WF, None; Huang GF, None.

REFERENCES

1 Xu XQ, Li SP, Xu YJ, Wei J. Prevalence of myopia among primary school students in mainland China: a Meta-analysis. Guoji Yanke Zazhi(Int Eye Sci) 2016;16(7):1221-1227.

2 Pan CW, Ramamurthy D, Saw SM. Worldwide prevalence and risk factors for myopia. Ophthalmic Physiol Opt 2012;32(1):3-16.

3 Pan CW, Dirani M, Cheng CY, Wong TY, Saw SM. The age-specific prevalence of myopia in Asia: a meta-analysis. Optom Vis Sci 2015;92(3): 258-266.4 He M, Huang W, Li Y, Zheng Y, Yin Q, Foster PJ. Refractive error and biometry in older Chinese adults: theLiwan eye study. Invest Ophthalmol Vis Sci 2009;50(11):5130-5136.

5 Liang YB, Wong TY, Sun LP, Tao QS, Wang JJ, Yang XH, Xiong Y, Wang NL, Friedman DS. Refractive errors in a rural Chinese adult population the Handan eye study. Ophthalmology 2009;116(11):2119-2127.

6 Fan DS, Lam DS, Lam RF, Lau JT, Chong KS, Cheung EY, Lai RY,Chew SJ. Prevalence, incidence, and progression of myopia of school children in Hong Kong. Invest Ophthalmol Vis Sci 2004;45(4):1071-1075.

7 Sainz-Gómez C, Fernández-Robredo P, Salinas-Alamán A, Montañés JM, Escudero Berasategui JM, Guillén-Grima F, Ruiz-Moreno JM,García-Layana A. Prevalence and causes of bilateral blindness and visual impairment among institutionalized elderly people in Pamplona, Spain.Eur J Ophthalmol 2010;20(2):442-450.

8 Cheng CY, Hsu WM, Liu JH, Tsai SY, Chou P. Refractive errors in an elderly Chinese population in Taiwan: the Shihpai Eye Study. Invest Ophthalmol Vis Sci 2003;44(11):4630.

9 Buch H, Vinding T, La Cour M, Appleyard M, Jensen GB, Nielsen NV.Prevalence and causes of visual impairment and blindness among 9980 Scandinavian adults: the Copenhagen City Eye Study. Ophthalmology 2004;111(1):53-61.

10 Verkicharla PK, Ohno-Matsui K, Saw SM. Current and predicted demographics of high myopia and an update of its associated pathological changes. Ophthalmic Physiol Opt 2015;35(5):465-475.

11 Koh V, Tan C, Tan PT, Tan M, Balla V, Nah G, Cheng CY, Ohno-Matsui K, Tan MM, Yang A, Zhao P, Wong TY, Saw SM. Myopic maculopathy and optic disc changes in highly myopic young Asian eyes and impact on visual acuity. Am J Ophthalmol 2016;164:69-79.

12 Samarawickrama C, Mitchell P, Tong L, Gazzard G, Lim L, Wong TY, Saw SM. Myopia-related optic disc and retinal changes in adolescent children from singapore. Ophthalmology 2011;118(10):2050-2057.

13 Chang L, Pan CW, Ohno-Matsui K, Lin X, Cheung GC, Gazzard G,Koh V, Hamzah H, Tai ES, Lim SC, Mitchell P, Young TL, Aung T, Wong TY, Saw SM. Myopia-related fundus changes in Singapore adults with high myopia. Am J Ophthalmol 2013;155(6):991-999.e1.

14 Asakuma T, Yasuda M, Ninomiya T, Noda Y, Arakawa S, Hashimoto S, Ohno-Matsui K, Kiyohara Y, Ishibashi T. Prevalence and risk factors for myopic retinopathy in a Japanese population: the Hisayama Study.Ophthalmology 2012;119(9):1760-1765.

15 Asai T, Ikuno Y, Akiba M, Kikawa T, Usui S, Nishida K. Analysis of peripapillary geometric characters in high myopia using swept-source optical coherence tomography. Invest Ophthalmol Vis Sci 2016;57(1): 137-144.

16 Mok KH, Lee VW. Disc-to-macula distance to disc-diameter ratio for optic disc size estimation. J Glaucoma 2002;11(5):392-395.

17 Saka N, Ohno-Matsui K, Shimada N, Sueyoshi SI, Nagaoka N,Hayashi W, Hayashi K, Moriyama M, Kojima A, Yasuzumi K, Yoshida T,Tokoro T, Mochizuki M. Long-term changes in axial length in adult eyes with pathologic myopia. Am J Ophthalmol 2010;150(4):562-568.e1.

18 Witmer MT, Margo CE, Drucker M. Tilted optic disks. Surv Ophthalmol 2010;55(5):403-428.

19 Fledelius HC, Goldschmidt E. Optic disc appearance and retinal temporal vessel arcade geometry in high myopia, as based on follow-up data over 38y. Acta Ophthalmol 2010;88(5):514-520.

20 Nonaka A, Hangai M, Akagi T, Mori S, Nukada M, Nakano N,Yoshimura N. Biometric features of peripapillary atrophy beta in eyes with high myopia. Invest Ophthalmol Vis Sci 2011;52(9):6706-6713.

21 Nakazawa M, Kurotaki J, Ruike H. Longterm fi ndings in peripapillary crescent formation in eyes with mild or moderate myopia. Acta Ophthalmol 2008;86(6):626-629.

22 Chui TY, Zhong Z, Burns SA. The relationship between peripapillary crescent and axial length: Implications for differential eye growth. Vision Res 2011;51(19):2132-2138.