INTRODUCTION

Diabetic muscle infarction (DMI) refers to spontaneous ischemic necrosis of skeletal muscle among people with diabetes mellitus, unrelated to atheroembolism or occlusion of major arteries. DMI is also referred to as spontaneous diabetic myonecrosis. Angervall and Sterner initially described DMI in 1965 as “tumoriform focal muscular degeneration”[1]. Although diabetes mellitus is a relatively common condition, DMI is a comparatively infrequent complication.

Diabetic nephropathy or other forms of chronic kidney disease are commonly seen in patients with DMI,affecting as many as 71%[2]. Of the diabetes-related microvascular complications, diabetic nephropathy is the most common one to be present among patients with DMI. Therefore, a proportion of DMI occurs in patients with end-stage renal disease (ESRD). However, little is known about the manifestation, diagnosis, management and outcomes of DMI in patients with ESRD.

This scoping review seeks to answer several questions about DMI regarding patient characteristics,clinical features, diagnostic evaluation, management and outcomes when this condition occurs in people with ESRD.

SEARCH STRATEGY AND STUDY IDENTIFICATION

The literature search was performed in July 2017 in four electronic databases. We searched MEDLINE/PubMed, CINAHL, SCOPUS and EMBASE with key words: (“Diabetic muscle infarction” OR “Diabetic myonecrosis”), AND (“Chronic kidney disease”OR “Renal impairment” OR “Dialysis” OR “Renal replacement therapy” OR “Renal transplant”). The search was done on publications between January 1980 and June 2017. Searches were limited to English language publications. Relevant references from articles identified from the search were also reviewed for comprehensive identification.

SELECTION OF STUDIES

This scoping review included cohort studies, case series and case reports with DMI in the setting of ESRD.Inclusion criteria include patients with ESRD requiring renal replacement therapy (RRT), clinical presentation of cases were adequately described, sufficient data on investigations, treatment and clinical outcome. The authors excluded studies that had not sufficiently eliminated trauma, inflammatory myositis, infection, neoplasm and deep vein thrombosis as possible aetiologies.

The selection process consisted of three stages. In thefirst stage, two reviewers (KK and TY) independently screened articles based on the title. In the case of doubt or disagreement, the articles were included in the abstract review stage. In the second stage, the abstracts of all articles are selected from the initial stage were reviewed and assessed by two reviewers (KK and TY).Any disagreement was resolved by discussion between the two reviewers. In the final stage, the remaining articles were fully reviewed using pre-determined inclusion criteria and assessed by two independent reviewers (KK and TY). Any disagreement between reviewers was solved by the two reviewers.

DATA EXTRACTION

4 Chester CS, Banker BQ. Focal infarction of muscle in diabetics.Diabetes Care 1986; 9: 623-630 [PMID: 3803154]

We identified 101 articles from our initial search. Six were excluded because these were published in non-English languages (Figure 1). Twenty-four publications containing 41 cases with DMI in the setting of ESRD were eligible to be included in this review[3-26].

PATIENT CHARACTERISTICS

Of the 41 patients with DMI in the setting of ESRD,22 occurred in women (53.7%). The mean age of presentation of all cases was 44.2 years (range:19.0-67.0 years). Of these, 17 (41.5%) had type 1 diabetes, 22 (53.7%) had type 2 diabetes and 2 (4.9%)had cysticfibrosis related diabetes (Table 1). One report did not provide information about the type of diabetes that the patient had. The two patients with cysticfibrosis also had lung transplantation. The mean duration of diabetes mellitus at the time of DMI diagnosis was 17.3 (range: 10.0-30.0) years for type 1 diabetes and 15.7 (range: 3.0-24.0) years for type 2 diabetes.Glycohemoglobin (HbA1c) values at the time of DMI diagnosis were reported in 18 cases and the average value was 7.2% (range: 5.0%-12.4%). Eleven out of 18(61.1%) had HbA1c above 7.0%.

采用SPSS 22.0 软件进行分析。以每个个体叶片性状的算术平均值作为该个体的性状值，采用单因素方差分析(one-way ANOVA)和Tukey后置检验法，对4个样地长柄双花木不同发育阶段叶功能性状的差异进行方差分析和差异显著性检验(α = 0.05)。采用Pearson相关性分析，对长柄双花木叶片功能性状与发育阶段(幼苗、幼树、成树)间的相关性进行检验并对各叶功能性状进行主成分分析(按照特征值大于1的原则提取主成分)，检验不同阶段叶性状症候群在主成分轴上的位置变化。由于叶片采集时是按树高和基径来划分发育阶段，所以发育阶段的数值以该发育阶段的平均树高代替。

All patients in this cohort had diabetic nephropathy.The RRT modalities included hemodialysis (25 patients;59%), peritoneal dialysis (9; 22%), combined kidneypancreas transplantation (4; 16%), kidney transplantation(1; 3%). For eight patients in whom information was provided, the mean duration of receiving dialysis was 2.1 years (range: 2 mo to 6 years). Twenty-four patients had concurrent retinopathy (58.5%) and 23 had peripheral neuropathy (56.1%). In terms of macrovascular diseases, six were reported to have coronary artery disease and three had peripheral arterial disease.

CLINICAL FEATURES

The most frequently affected muscle groups were in the lower limbs (36; 87.8%), in comparison with the upper limbs which were reported only infive cases[11,22].In the lower limb, DMI more commonly affected the proximal leg (24/36; 66.7% of those with lower limb involvement) than distal leg, i.e., below knee (6/36;16.7%). Six patients (16.7%) had both proximal and distal leg muscles involved. Most had unilateral (80.5%)involvement on initial presentation, while eight cases had bilateral involvement. Sixteen (39.0%) involved multiple muscle groups on initial presentation.

The most common clinical presentation of DMI was abrupt onset of pain in the affected muscle group(100%), accompanied by local swelling (97.6%). Fever was reported in six patients (14.6%). In the current analysis, compartment syndrome has been reported in one case[23].

INVESTIGATIONS

Results of laboratory investigations are usually nonspecific for DMI. White cell count (WCC) values were reported in 35 cases but only 31.4% were elevated(Table 2). One patient was found to be leucopenic[15].Inflammatory markers are commonly increased in DMI.C-reactive protein (CRP) was reported in 11 cases and was elevated in nine (81.8%) (Table 2). The mean CRP in these cases was 153.6 mg/L (range: 5.0-361.0 mg/L).Erythrocyte sedimentation rate (ESR) in nine cases and was increased in eight (88.9%) (Table 2). The mean ESR was 82.9 mm/h (range: 3.0-137.0 mm/h).

Creatine kinase (CK) values were reported in 34 cases but was elevated in 50.0% (considered as greater than 150.0 IU/L for females or 250.0 IU/L for males)(Table 2). When measured on initial presentation, the mean absolute CK was 292.9 IU/L (range: 23.0-1066.0 IU/L).

企业通过标准系统来规范企业生产、经营秩序，改进产品和服务的适用性，创造更多的效益。因此，不断完善企业标准系统是企业的一项重要工作。然而，传统的标准系统管理手段，如运用计划、组织、监督、调节等职能来协调标准系统内部要素之间关系和系统与外部环境关系，已经不适应现代企业生产经营要求，需要探索利用标准系统理论的方法来提升企业标准化管理水平。

Magnetic resonance imaging (MRI) was performed in most patients (35/41; 85.4%). The common abnormalities observed on MRI is muscle enlargement(33/35; 94.2%) and muscle oedema with hyperintense T2 signal (30/35; 85.7%) (Table 2). Other findings include subcutaneous edema (17/35; 48.6%).

Ultrasound was performed in 28 (68.3%) patients but all were done to exclude deep vein thrombosis.Subcutaneous or muscle edema on ultrasound was reported in six cases (21.4%). Computed tomography(CT) was performed less frequently among cases included in this review (12/41; 29.3%).

Muscle biopsy was performed in 16 cases (39.0%).Biopsies usually demonstrate muscle necrosis (100%)and inflammatory cell infiltration (87.5%) (Table 2). In some cases, muscle fibre regeneration (43.8%) wasalso present.

MANAGEMENT

Treatment details were provided in 36 cases. Most patients (31/36; 86%) were managed with analgesia.Four patients received aspirin therapy. There was no clear description in most cases as to whether patients rested in bed or received physiotherapy. Five patients(13.8%) required surgical intervention, which involved debridement of the affected muscle.

In a small number of patients, intensification of glycaemic control (four patients) and dialysis (one patient)were reported. Seven patients received other forms of treatment which included antibiotics, prednisolone and erythropoietin therapy. However, the effectiveness of these treatments could not be ascertained in this review due to the limited numbers.

Outcomes

As the management approaches to DMI vary considerably in between patients, the efficacy of each treatment modality or the comparisons of outcomes could not be evaluated in this small sample size. In 15 patients, the time interval between diagnosis and resolution of the initial presentation of DMI was 1.4 mo(range: 2 wk to 4 mo).

Recurrent muscle infarctions were reported in 43.9% of cases. None of the pancreas-kidney transplant recipients experienced any recurrence of DMI. Of those with recurrence of DMI, the mean time interval between the initial episode and thefirst recurrence was 5.3 mo(range: one week to 18 mo). Most of the recurrences in this case series occurred in a different muscle group to the initial episode (9/11; 81.8%).

In the cases reviewed, seven patients died during the follow-up period after developing DMI. Five of these patients were receiving haemodialysis and two were on peritoneal dialysis. No death was reported among kidney transplant recipients with DMI.

DISCUSSION

DMI is a rare disorder encountered in patients with longstanding diabetes mellitus and end-organ complications. Among patients with ESRD, the manifestation of DMI, investigation findings, management approach and rate of recurrence are similar to the other patients without ESRD who develop DMI. However, this study was not designed to estimate the incidence of DMI among patients with ESRD.

In a review by Trujillo-Santos et al[27] of 166 episodes of DMI in 115 patients, the mean age at the time of presentation was 42.6 years. The mean duration between diagnosis of diabetes mellitus andfirst episode of DMI was 14.4 years. In the present review, those with DMI in the setting of ESRD also have a similar age at the time of presentation and duration of diagnosis with diabetes mellitus. As this was a review of case report and series, it is not possible to determine if there is any difference in incidence of DMI between type 1 and type 2 diabetes. Similarly, any difference in incidence between patients who receive hemodialysis and peritoneal dialysis cannot be established in this review. Nonetheless, this review indicates that DMI can occur in patients after kidney transplantations including combined pancreas and kidney transplantations. Unsurprisingly, most patients have other concurrent diabetes-related microvascular complications such as retinopathy and peripheral neuropathy. In relation to patient characteristics, the current cohort of patients with ESRD and DMI was relatively similar to an unselected group of patients with DMI[2].

There is a propensity for DMI to occur among patients with longstanding diabetes mellitus whose glycaemic control has deteriorated over time. More than 60% of ESRD patients who develop DMI have HbA1c of greater than 7.0%, which indicated inadequate glycaemic control. DMI has been reported in a number of cases with poor glycaemic control[28]. The pathophysiology for DMI is still unknown but several hypotheses have been suggested. Atherosclerotic changes, diabetes-related microangiopathy, vasculitis with associated thrombosis,and ischemia-reperfusion injury have been postulated as possible mechanism for DMI[29]. The thromboembolic mechanism is thought to involve endothelial damage resulting in tissue ischemia which leads to muscle injury and ischaemic necrosis. Reperfusion of ischaemic muscles lead to increase in oxygen radicals and reduced nitric oxide, which in turn releases inflammatory mediators. Alterations in the coagulation-fibrinolysis system resulting in damage of vascular endothelium and hypercoagulability have also been suggested as part of the pathophysiology of DMI[30].

28 Chebbi W, Jerbi S, Klii R, Alaya W, Mestiri S, Zantour B, Sfar MH. Multifocal diabetic muscle infarction: a rare complication of poorly controlled diabetes mellitus. Intern Med 2014; 53: 2091-2094[PMID: 25224194 DOI: 10.2169/internalmedicine.53.2322]

Although MRI findings are not pathognomonic for DMI, this modality is still the most sensitive and specific for diagnosis of this condition[2]. Characteristic features on MRI include muscle enlargement, oedema within affected muscles, subcutaneous and interfascial oedema[32].On MRI examination, the differential diagnoses include intramuscular abscess, inflammatory myositis and necrotising fasciitis[27]. Sometimes it can be difficult to distinguish these entities and muscle biopsy may be required. Other imaging modalities such as ultrasound or CT scans may assist in excluding other disorders but may not enable the correct diagnosis of DMI. In patients with ESRD, calciphylaxis or calcific uremic arteriolopathy (CUA)also needs to be considered in the differential diagnosis.CUA is characterized by vascular and other soft tissue calcification, intimal hypertrophy, and thrombosis of small vessels that results in painful tissue necrosis, including skeletal muscle[33]. The ischaemic injury in DMI is more confined to the muscle whereas in CUA, cutaneous and other soft tissues can be affected. A histopathological feature of CUA will often reveal extensive calcification,microthrombosis and endovascular fibrosis of small subcutaneous arteries leading to cutaneous ischemia whereas the calcification is not a prominent feature of DMI[33].

Muscle biopsy can lead to a conclusive diagnosis but this is not currently recommended because of the risk from procedure-related complications[34]. It can be used as a diagnostic tool in atypical presentations of DMI.Histopathological changes in DMI can vary depending on the timing of biopsy. In general, DMI presents as a pale nonhemorrhagic muscle. Initially, light microscopy would usually show muscle necrosis and phagocytosis of necrotic musclefibres. At a later stage, the necrotic muscles are replaced by fibrous tissue, lymphocyte infiltration and muscle regeneration.

Blood investigations are generally non-specific for DMI. Surprisingly, a rise in CK has only been reported in half of the patients with DMI and ESRD. It is possible that the lack of rise in CK may be related to the delay in some patients seeking attention and measurement is performed after this marker has peaked. This is relatively consistent with other systematic review of unselected patients with DMI. CRP and ESR were commonly elevated in DMI but these markers were not specific for this condition.

23 De Vlieger G, Bammens B, Claus F, Vos R, Claes K. Diabetic muscle infarction: a rare cause of acute limb pain in dialysis patients. Case Rep Nephrol 2013; 2013: 931523 [PMID: 24563799 DOI: 10.1155/2013/931523]

企业若想使自身市场竞争力获得有效提升就必须更加重视物流成本管理，由于我国的物流市场需求十分庞大，所以我国企业在物流成本方面仍具有一定的优势，且物流发展空间相对良好，而企业若想抓住以上优势就必须认真开展物流成本管理，对企业物流成本管理目标予以整体把握，提升企业成本会计制度的完善程度，更加致力于成本控制机制的创新，对物流流程予以整合及优化，提升企业资源的利用效率，只有这样企业才能在降低成本的同时持续提升自身服务质量，达到增加自身市场竞争能力的根本目的。

The short-term prognosis of DMI is good and most patients recover within 6 mo but recurrence is frequent among patients with ESRD. Almost 50% will experience recurrence of DMI, mostly in another muscle group,within 6 mo after the initial episode. In comparison to unselected patients with DMI, the recurrence rate was reported at 29.2%[2]. It was interesting to observe that no recurrence has been reported among transplant recipients. Further research is needed to confirm this observation. The long-term survival of patients with DMI can be variable. Death within a year by an episode of DMI are often related to other end-organ complications present in these patients.

The present review is limited by the use of case reports or series with the largest one having four patients.Not all patients had the same type of investigations for DMI. There are also limited reports about functional impairment experienced by patients during episodes of DMI. Furthermore, follow-up of patients in the included reports varied considerably.

More research is needed to better understand the pathogenesis of DMI, strategies for effective treatment and prevention of recurrence. More specifically, in the setting of ESRD and RRT, more investigation is needed to ascertain if adequacy of the RRT may influence outcomes. It will also be useful to better understand the natural history of DMI among patients who have had renal transplantation or those who are candidates for transplantation.

CONCLUSION

DMI is an uncommon complication of diabetes mellitus that can also affect patients with ESRD who are receiving dialysis or recipients of kidney transplantation.Clinical findings which supported by MRI examination is currently the best approach to confirm the diagnosis of DMI. Muscle biopsy is not recommended but may be required in atypical presentations. The best management approach for DMI is currently unclear and present practice is still largely based on expert opinion because of limited evidence. Nonetheless, nonsurgical treatment appears to be a better option than surgical intervention.The short-term prognosis of DMI is good but recurrence is frequent.

REFERENCES

近年来，“生物圈中的绿色植物”（考查）考试的目标要求有两个层次，即了解和理解，其中了解的目标有5个，理解的目标有6个。

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A standardized template was used to extract data from the included studies using the following heading:general information such as title of article, main author and publication year, patient or cohort characteristics,type of diabetes mellitus, type of RRT (hemodialysis,peritoneal dialysis and kidney transplant), microvascular complications (retinopathy and peripheral neuropathy),macrovascular complications (coronary artery disease,ischaemic strokes and peripheral arterial disease)and pattern of muscle involvement. Laboratory and radiological investigationfindings during initial evaluation or during recurrence were also obtained. Clinical outcomes to be considered in this review include time to recovery from DMI, recurrence rate and death during the follow-up period.

1.2.5.3 .2做好床边交接班。要重视:要跟你说话的病人,夜间处置过的病人,治疗效果不好及重病人,特殊病人让护士做好告知签字。

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4)回缩。多年生枝的短截修剪，称回缩修剪，也叫缩剪。缩剪比短截的局部促进作用更强，有助于养分向基部转移。成龄树冬剪时应用较多。

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1) 水胶比W/C大小是影响大孔生态混凝土力学性能的重要因素，在满足工作性能及浆体包裹均匀程度的前提下，尽量使用较低的W/C；

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该模型可以用来描述从xk-1到xk的过渡过程,本文采用了一个低运动估计,通过随机游走过程建立每一次迭代模型,其方差为同时,Zk可表示为

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㉒参见龚廷泰《当代法律帝国主义的本质及其表征——以列宁〈帝国主义论〉为方法论视角》，《法治现代化研究》2017年第5期。

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单点登录（Single Sign On，简称 SSO）允许用户在多个应用系统中只登录一次就可以访问所有相互信任的应用系统。这样不仅可以避免多次认证给用户带来的麻烦，提升用户体验，而且降低了安全风险和管理消耗。有单点登录，自然就有单点注销，在一个系统中注销，所有系统的会话都将被注销。

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Early recognition of DMI is important for prompt initiation of treatment. Among patients with DMI and ESRD, supportive care consisting of analgesia was the main management approach. Generally, patients with DMI also receive intensive glycaemic control. Some clinicians have recommended avoiding physical therapy during the acute phase of DMI because it can prolong recovery but others have not observed this[4,35]. Surgical intervention is required only in selected cases but this is notfirst-line option because of association with a more prolonged recovery[14]. Other treatment modalities such as glucocorticoid, antibiotics and erythropoietin have been tried but their efficacy in DMI is uncertain.

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The diagnosis of DMI remains challenging and can lead to underdiagnosis[31]. At present, the diagnosis of DMI involves the combination of clinical assessment,MRI and muscle biopsy with atypical presentations. DMI is characterized by localized muscular pain, swelling and tenderness and there is a more frequent involvement of the lower limb musculature, especially the thigh. Rare cases of upper limb muscle involvement have been reported[11,22]. The reason for this predilection for lower limb muscles is uncertain.

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幼儿园的课程以游戏为主，强调玩中学，学习内容直观、具体、形象。而进入小学后，学习成为了重头戏，集中课堂又多以老师说学生听为方式来进行，孩子动手操作实践的机会大大减少了。相比于幼儿园，这种学习方式较为单调、枯燥，容易造成孩子的不适应。

在这样的学术背景下，上海交通大学刘华文教授《翻译诗学》一书的出版无疑是及时而可贵的。正如顾明栋（2015：vii）教授在该书序中所说，该书“精当地将翻译和诗学、中西哲学和美学、中西文论和语言理论、中国译学史料和翻译实践相结合，已初步构建成一个学贯中西、打通古今、理论联系实践的体大思精之作，可以说是迄今为止最好的一部中国翻译诗学。”

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